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Eprex (Epoetin Alfa) is a glycoprotein, produced by recombinant DNA technology, that contains 165 amino acids in a sequence identical to that of endogenous human erythropoietin . Recombinant epoetin has the same biological activity as the endogenous hormone, which induces erythropoiesis by stimulating the division and differentiation of committed erythroid progenitor cells , including burst-forming units–erythroid, colony-forming units–erythroid, erythroblasts, and reticulocytes in bone marrow. Erythropoietin also induces the release of reticulocytes from the bone marrow into the blood stream, where they mature into erythrocytes . Buy Eprex (Epoetin Alfa)
Endogenous erythropoietin is produced primarily in the kidney. The anemia associated with chronic renal failure is caused primarily by inadequate production of the hormone . Administration of Eprex (Epoetin Alfa) corrects the erythropoietin deficiency in patients with chronic renal failure. Eprex (Epoetin Alfa) also stimulates red blood cell production in patients who do not have a documented erythropoietin deficiency, i.e., patients with normal or slightly elevated concentrations of endogenous erythropoietin. However, it may not be effective in patients who are anemic despite having significantly elevated concentrations of erythropoietin.
The increase in hematocrit induced by Eprex (Epoetin Alfa) may increase blood viscosity and peripheral vascular resistance, leading to a rise in blood pressure. The medication does not appear to have a direct pressor effect.
Eprex (Epoetin Alfa) may correct the bleeding tendency associated with chronic renal failure, which may be caused partially by red blood cell deficiency . However, the medication may also increase the thrombotic tendency in some patients. Buy Eprex (Epoetin Alfa) online
Correction of anemia by Eprex (Epoetin Alfa) may result in an improved feeling of well-being; increased appetite; relief of anemia-induced fatigue, tachycardia, headache, weakness, or angina pectoris; increased exercise tolerance and physical activity; and improved sleep, sexual function, and cognitive function.
Administration of Eprex (Epoetin Alfa) apparently does not induce antibody formation, because antibodies have not been detected in the blood of patients treated with the recombinant hormone for up to 12 months.
Endogenous erythropoietin production may be suppressed by chronic administration of recombinant Eprex (Epoetin Alfa). Buy Eprex online
Elimination—May average 4 to 13 hours following intravenous or subcutaneous administration. The elimination half-life is generally higher after the first few doses (> 7.5 hours) than after 2 or more weeks of treatment (6.2 hours after 7 doses; 4.6 hours after 24 doses). Buy Eprex uk
Note: The pharmacokinetic profile of Eprex (Epoetin Alfa) in children and adolescents is similar to that of adults.
Onset of action:
Increase in reticulocyte count (initial effect)—Within 7 to 10 days.
Increase in red cell count, hematocrit, hemoglobin—Clinically significant increases generally occur in 2 to 6 weeks. The rate and extent of the response are dependent on dosage and availability of iron stores. Over a 2-week period, administration of 50 Units per kg of body weight 3 times weekly increases the hematocrit by an average of 1.5 points, administration of 100 Units per kg of body weight 3 times weekly increases the hematocrit by an average of 2.5 points, and administration of 150 Units per kg of body weight 3 times weekly increases the hematocrit by an average of 3.5 points. Buy Eprex
Time to peak concentration:
Single intravenous dose—15 minutes.
Single subcutaneous dose—5 to 24 hours. Peak concentrations may be maintained for 12 to 16 hours, and detectable quantities are present for at least 24 hours, after administration. Buy Eprex 4000 online
Note: With repeated subcutaneous administration, peak concentrations are achieved and maintained over the same time periods as with single subcutaneous doses, but are substantially lower than those achieved by a single dose. However, the lower Eprex (Epoetin Alfa) concentrations are sufficient for achieving, and even lower concentrations are sufficient for maintaining, the desired response. Buy Eprex 2000
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